There was a problem starting uplay_r1_loader64.dll.Try reinstalling the program to fix this problem. The program can't start because uplay_r1_loader64.dll is missing from your computer.The most commonly occurring error messages are: For instance, a faulty application, uplay_r1_loader64.dll has been deleted or misplaced, corrupted by malicious software present on your PC or a damaged Windows registry. Errors related to uplay_r1_loader64.dll can arise for a few different different reasons.